One proof of this is identical twins identical twins have identical genes yet when one twin has type 1 diabetes the other gets the disease at most only half the time when one twin has type 2 diabetes the others risk is at most 3 in 4 type 1 diabetes in most cases of type 1 diabetes people need to inherit risk factors from both parents. Diabetes can run in families but it does not always happen if there is a genetic link why do only some people in the family develop diabetes find out more about how various factors including . Diabetes is a complex condition several factors must come together for you to develop type 2 diabetes for example obesity and a sedentary lifestyle play a role genetics can also influence . Since type 1 diabetes is an autoimmune disease your body destroys the cells that make insulin it makes sense that hla genes are front and center there are thousands of versions of them in the . The causes of type 1 diabetes are unknown although several risk factors have been identified the risk of developing type 1 diabetes is increased by certain variants of the hla dqa1 hla dqb1 and hla drb1 genes these genes provide instructions for making proteins that play a critical role in the immune system
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